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The chmp gave a positive opinion on 24 april 2008 recommending the harmonisation of the spc, labelling and package leaflet for cozaar and associated names.

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To reduce the risk of dizziness and lightheadednessget up slowly when rising from a sitting or lying position.

COZAAR is available as tablets for oral administration containing either 25 mg50 mg or 100 mg of losartan potassium and the following inactive ingredientsmicrocrystalline celluloselactose hydrouspregelatinized starchmagnesium stearatehydroxypropyl cellulosehypromelloseand titanium dioxide.

Cozaar is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.

Plasma clearance of losartan and its active metabolite is about 600 ml/min and 50 ml/minrespectivelyRenal clearance of losartan and its active metabolite is about 74 ml/min and 26 ml/minrespectivelyWhen losartan is administered orallyabout 4of the dose is excreted unchanged in the urineand about 6of the dose is excreted in the urine as active metaboliteThe pharmacokinetics of losartan and its active metabolite are linear with oral losartan potassium doses up to 200 mg.

As observed for angiotensin converting enzyme inhibitorslosartan and the other angiotensin antagonists are apparently less effective in lowering blood pressure in black people than in non-blackspossibly because of higher prevalence of low-renin states in the black hypertensive population.

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